The second round of the 2011 NFL Draft featured a new hook this year as a former player for each team read the pick aloud on stage. For the Denver Broncos it was Shannon Sharpe (and a fan who did the second pick of the round). Marshall Faulk, Barry Sanders and Franco Harris were among the other participants.
The Buccaneers may have gotten the steal of the round at No. 51 if Da'Quan Bowers proves to be healthy. He was top-10 pick at one point.
Here is the complete second round selections:
| Pick | Team | Player | Pos | College |
| 33 | Patriots | Ras-I Dowling | DB | Virginia |
| 34 | Bills | Aaron Williams | DB | Texas |
| 35 | Bengals | Andy Dalton | QB | TCU |
| 36 | 49ers | Colin Kaepernick | QB | Nevada |
| 37 | Browns | Jabaal Sheard | DL | Pittsburgh |
| 38 | Cardinals | Ryan Williams | RB | Virginia Tech |
| 39 | Titans | Akeem Ayers | LB | UCLA |
| 40 | Cowboys | Bruce Carter | LB | North Carolina |
| 41 | Redskins | Jarvis Jenkins | DL | Clemson |
| 42 | Texans | Brooks Reid | DL | Arizona |
| 43 | Vikings | Kyle Rudolph | TE | Notre Dame |
| 44 | Lions | Titus Young | WR | Boise St. |
| 45 | Broncos | Rahim Moore | FS | UCLA |
| 46 | Broncos | Orlando Franklin | OL | Miami |
| 47 | Rams | Lance Kendricks | TE | Wisconsin |
| 48 | Raiders | Stefen Wisniewski | OL | Penn St. |
| 49 | Colts | Ben Ijalana | OL | Villanova |
| 50 | Chargers | Marcus Gilchrist | DB | Clemson |
| 51 | Buccaneers | Da'Quan Bowers | DE | Clemson |
| 52 | Giants | Marvin Austin | DL | North Carolina |
| 53 | Bears | Stephen Paea | DT | Oregon St. |
| 54 | Eagles | Jaiquawn Jarrett | DB | Temple |
| 55 | Chiefs | Rodney Hudson | OL | Florida St. |
| 56 | Patriots | Shane Vereen | RB | California |
| 57 | Lions | Mikel Leshoure | RB | Illinois |
| 58 | Ravens | Torrey Smith | WR | Maryland |
| 59 | Browns | Greg Little | WR | North Carolina |
| 60 | Texans | Brandon Harris | DB | Miami |
| 61 | Chargers | Jonas Mouton | LB | Michigan |
| 62 | Dolphins | Daniel Thomas | RB | Kansas St. |
| 63 | Steelers | Marcus Gilbert | OL | Florida |
| 64 | Packers | Randall Cobb | WR | Kentucky |