Andy Parrino put San Diego in the lead in the second with an RBI double. Jesus Guzman drove in the other three San Diego runs in the third on a three-run home run.
Colorado scored its runs in the seventh when Chris Nelson doubled in a run. Charlie Blackmon followed with an RBI single and D.J. LeMahieu drove in the final run with a sacrifice fly.
Casey Kelly (2-1, 5.85 ERA) picked up the win after giving up three runs (two earned) and striking out six in six innings. Drew Pomeranz (1-9, 5.06 ERA) took the loss for Colorado.