Millwood (0-1, 3.86 ERA) gave up all of the home runs, two in the fourth inning to Edgar Renteria and Jay Bruce. Joey Votto's 18th of the season put the Reds ahead, 3-2. Millwood finished seven innings and struck out six in his first game of the season.
The Rockies' offense pounded out 13 hits, but only two runs crossed home plate. Dexter Fowler singled in a run in the fifth inning and Troy Tulowitzki hit his 23rd home run of the season in the sixth inning. Reds starter Mike Leake (10-7. 3.84 ERA) struck out five and allowed 11 of the 13 hits.
In the ninth inning, Eric Young Jr. entered the game as a pinch-runner after Eliezer Alfonzo doubled. Young stole third but was tagged out in a run down between third base and home plate on a Dexter Fowler fielder's choice. Chris Nelson also hit into a fielder's choice, which resulted in Dexter Fowler tagged out at third base to end the game.
The Rockies (55-63, 27-32 away) finish this series with an afternoon game on Thursday. Johnny Cueto and Jhoulys Chacin are the scheduled starters.