Fowler appeared to roll his ankle while heading into second base after singling and advancing on a throw to third. Infielder Jordan Pacheco was brought in as a pinch-runner to replace Fowler, who limped off the field while noticeably in pain. The Rockies trailed the Mets 1-0 when the injury occurred, but were able to tie the game two batters later.
Fowler, 26, is in the midst of a breakout season for the Rockies. Through Tuesday's action, he was hitting .306/.392/.499 in 435 plate appearances. The Rockies have dealt with numerous injuries during the 2012 season; among others, star shortstop Troy Tulowitzki hasn't played since May 30 while dealing with hip and groin injuries, and first baseman Todd Helton is out for the season following hip surgery.