Colorado College was tied 2-2 with Minnesota in the third period before the Golden Gophers took over late.
Colorado College dropped the opener of the WCHA series at the World Arena when they fell to No. 4 Minnesota, 4-2, on Friday.
The Golden Gophers built a 2-0 lead in the second period before the Tigers stormed back to tie the game at 2-2 on goals by Archie Skalbeck and William Rapuzzi heading into the third period.
Minnesota left winger Tom Serratore broke the tie at the 13:23 mark of the third period with his fifth goal of the season to put the Golden Gophers up for good. Minnesota added an empty-net goal with 1:08 remaining in the third to secure the win.
Colorado College has struggled to win close games this season as they are are 4-6-1 in games decided by one goal this season.
The loss dropped Colorado College to 8-8-1 on the season as they have played teams ranked in the top-seven in four consecutive weeks. Minnesota improved to 11-3-2 overall with the win.