Chris Stewart and Peter Stastny each had a goal and an assist for the Avalanche, who have won their past two games.
Derick Brassard scored the lone goal for the Blue Jackets, who had a three- game winning streak snapped. Steve Mason started in net, but was lifted in the second period as he gave up four goals on 19 shots. Mathieu Garon stopped 11- of-12 shots the rest of the way.
Colorado got on the board at the 4:14 mark of the first period when David Jones beat Mason with a wrister for his fourth goal of the season.
The Avs scored three times in the middle period to take command of the game.
On the power play, Stewart, who notched a hat trick against Calgary on Thursday, scored his ninth goal of the year just 50 seconds in.
Exactly halfway through the frame, David Liffiton scored the first goal of his NHL career on a big blast and Stastny made it a 4-0 game just 44 seconds later.
Cody McLeod scored at the 6:06 mark of the third period while Brassard broke up the shutout bid with a power-play goal at the 8:37 mark on his third marker of the season.
Colorado has off until Thursday when it will host Vancouver...Columbus hosts Montreal on Tuesday...Colorado took all four games last season after Columbus did the same in the 2008-09 campaign...Stewart has an eight-game point streak and has recorded eight goals and six assists during that time. Linemate Milan Hejduk, who notched two assists in the game, has three goals and eight assists during a six-game point streak.
The Colorado Avalanche offense showed up during the first 10 minutes of the second period for three goals. On the power play, Chris Stewart added his ninth goal of the season 50 seconds into the period. Roughly 10 minutes later, defenseman David Liffiton scored the first goal of his career. Forty-four seconds later, Paul Stastny netted another goal for the Avalanche for a 4-0 lead.
Goalie Peter Budaj is still perfect in net tonight, blocking 19 shots.
At the end of one period of play, the Colorado Avalanche are up 1-0 on David Jones’ fourth goal of the season. Goalie Peter Budaj has blocked all 11 shots he has faced, which is much better than his last two games.
Three straight one-goal victories have given the Blue Jackets their longest winning streak since also claiming three straight decisions from Feb. 4-10. Columbus hasn't posted four wins in a row since March 7-13, 2009.
Columbus' most recent triumph came past regulation as it knocked off visiting Edmonton, 3-2, in a shootout on Thursday. Rick Nash and Nikita Filatov both scored in the deciding segment and Steve Mason turned aside both Oiler chances after making 25 saves in regulation and overtime.
"Sometimes you win ugly and sometimes you win in dramatic fashion," said Columbus head coach Scott Arniel. "It was a wild and scrambly game, and I knew it was going to be that kind of game, wide open. It was pretty much what I expected."
The Blue Jackets, who are 3-0-0 on the road this year, were without both Kristian Huselius (foot/ankle) and Jan Hejda (strained calf).
While Columbus is on a roll, Colorado tonight seeks to win consecutive games for only the second time this season. The Avalanche halted a three-game slide on Thursday with a 6-5 triumph in Calgary.
Chris Stewart recorded his second career hat trick and Daniel Winnik scored the deciding goal with 2:20 left to play. Ryan O'Reilly had three assists, including the primary one on Winnik's tally.
"This is a very big win for us," Avs head coach Joe Sacco said. "We had some timely goal scoring."
Peter Budaj made his second straight start after No. 1 netminder Craig Anderson hurt his knee in pregame warmups on Tuesday and made just 14 saves. Budaj will likely be in net again tonight and is 5-4-0 with a 2.47 goals- against average in his career versus Columbus.
Stewart has seven goals and five assists over a seven-game point streak and has four goals in seven career games versus the Blue Jackets. Milan Hejduk also had an assist to run his point streak to five games (3 goals, 6 assists), but John Michael Liles had his assists streak end at nine, an NHL record for a defenseman to start a season.
Colorado, which begins a four-game homestand tonight, outscored Columbus 16-7 in sweeping last year's four-game set, one season after the Blue Jackets took all four meetings. Columbus has still lost five of seven and 15 of 18 in Colorado.